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M9550858.TXT
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1995-03-25
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Document 0858
DOCN M9550858
TI Isolated toxoplasmosis of the thoracic spinal cord in a patient with
acquired immunodeficiency syndrome. Case report.
DT 9505
AU Resnick DK; Comey CH; Welch WC; Martinez AJ; Hoover WW; Jacobs GB;
Department of Neurological Surgery, University of Pittsburgh; School of
Medicine, Pennsylvania.
SO J Neurosurg. 1995 Mar;82(3):493-6. Unique Identifier : AIDSLINE
MED/95165220
AB Toxoplasmosis and lymphoma are the two most common causes of
intraparenchymal cerebral mass lesions in patients with acquired
immunodeficiency syndrome (AIDS). The clinical and radiographic features
of the intracranial lesions have been well described. Because of the
high frequency of toxoplasmosis in the AIDS population, common therapy
for patients presenting with intracranial mass lesions consists of an
empirical trial of anti-Toxoplasma chemotherapy, with biopsy reserved
for cases demonstrating features considered to be more consistent with
lymphoma, or for lesions that do not improve despite adequate
anti-Toxoplasma treatment. A similar treatment algorithm does not exist
for intramedullary lesions of the spinal cord. The authors describe a
patient who presented with paraparesis resulting from an isolated
thoracic intramedullary lesion. An open biopsy of the lesion revealed
characteristic structures containing Toxoplasma tachyzoites. The
clinical and radiographic presentation of the lesion is discussed, the
available literature is reviewed, and a treatment strategy for spinal
cord lesions in AIDS patients is proposed.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Biopsy Case Report
Human Magnetic Resonance Imaging Male Middle Age Spinal
Cord/PATHOLOGY Spinal Cord Diseases/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY
Toxoplasmosis/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).